In-depth analyses of probiotic benefits, mechanisms and challenges aiming to advance probiotic knowledge at large

Strategic Vision

The task force aims at providing recommendations for beneficial probiotics usage for various target groups.

Background

Probiotic bacteria may be defined as ‘live microorganisms that, when administered in adequate amounts, confer a health benefit on the host’ (Hill et al, 2014). Consumers, the scientific community, regulators and the food industry show a sustained interest in these microorganisms and related functional effects.

Objectives

  • The growing public interest on probiotics needs to be sustained by a better scientific understanding on their role and mechanism of action.
  • Increase awareness of the real impact of probiotics direct/indirect effects on health.Three publications that examine the intestinal barrier, its role in health and disease and the potential impact of probiotics on intestinal barrier function were published recently. J. Wells et al., 2016 describes the role of different defense mechanisms that support barrier function, how they are regulated and measured. It also focuses on biomarkers in blood, faeces or urine that can be used to assess intestinal permeability and epithelial integrity. J. König et al., 2016 discuss the role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), obesity, coeliac disease, non-coeliac gluten sensitivity and food allergies. P. Bron et al., 2017 catalogue and categorise the lines of evidence available in literature for the role of probiotics in intestinal epithelial integrity and, consequently, their beneficial effects for the reduction of gastrointestinal disease symptoms.

The task force is planning to organise a joint session on the ‘Gut-Brain Axis’ during the 40th European Congress for Nutrition and Metabolism (ESPEN) Congress, in September 2018, Madrid, Spain, with the task forces on Nutrition, Immunity & Inflammation, Nutrition & Mental Performance and Prebiotics.

Achieved Results

  • The collaboration with the Prebiotics Task Force resulted in a Concise Monograph (Binns, 2013) that summarises the science and principles valid for prebiotics, probiotics and synbiotics today. This publication is often used as teaching material by students and SMEs.
  • The output of the expert group on ‘Mechanism of Probiotics Action’ has been disseminated at the Beneficial Microbes Conference 2018 and at Probiota 2019.

Scientific Impact

  • The activity on ‘Gut Barrier Function’ produced 3 manuscripts (J.M. Wells et al., 2016, J. Köning et al., 2016, P.A. Bron et al., 2017) that have been cited altogether 311 times.
  • The supplement in Journal of Nutrition titled ‘Guidance for Assessing the Probiotics Beneficial Effects: How to Fill the Gap’ (J. Neu, 2010) provides guidelines to support the design of probiotics studies that are intended to examine probiotics interactions with the gut and the microbiome. The 5 articles featured in the supplement received 741 citations in total.

For more detailed information, please contact Michela Miani at mmiani@ilsieurope.be or Toula Aslanidis at taslanidis@ilsieurope.be

Task Force Members

*Scientific Advisor

Expert Groups

Joint Nutrition Cluster Activity on ‘Mechanistic Insights into the Gut-Brain Axis’ – In collaboration with Early-Life and Long-Term Health; Health Benefits Assessment of Foods; Nutrition, Immunity & Inflammation; Nutrition & Mental Performance; and Prebiotics Task Forces. – NEW

Background & Objectives

Currently, half of the literature available on the gut-brain axis is state-of-the-art reviews or correlative studies and comprehensive mechanistic insights underlining the bidirectional communication between the gut and the brain are lacking.
In this context, several Nutrition Task Forces decided to join forces to understand where we stand today regarding the mechanisms and more specifically to:

  • focus on translational aspects from pre-clinical to clinical studies;
  • focus on lifespan-related changes (but not disease-related) in gut structure and function which play a role in long-term immune and brain health;
  • discuss the nutritional and lifestyle interventions with positive impact on the lifespan gut structure/function and thus on immune and brain health.

Output

A workshop will bring together key experts from different fields of expertise to debate and discuss on the current knowledge and data gaps, followed by a live-streamed debate leading to the publication of a report/position paper. A series of webinars will then be organised to discuss the identified gaps in more details.

Expert Group Members

Joint Nutrition Cluster Activity on ‘Mechanistic Insights into the Gut-Brain Axis’ – In collaboration with Early-Life and Long-Term Health; Health Benefits Assessment of Foods; Nutrition, Immunity & Inflammation; and Nutrition, Mental Performance & Prebiotics Task Forces – New

Posters

Monitoring Immune Modulation by Nutrition in General Population: Identifying and Substantiating Effects on Human Health

Exploring the Interactions between Probiotics and Health

Publications

Filter

All Publications

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => Probiotics
            [authors] => 
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Probiotics
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => Probiotics
            [authors] => 
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Probiotics
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
            [taxonomy] => ilsi_committee
            [term_id] => Probiotics
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [terms] => Array
                                (
                                    [0] => Probiotics
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_3_term_relationships
                )

            [queried_terms] => Array
                (
                    [ilsi_committee] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => Probiotics
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_3_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_3_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_3_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_3_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_3_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_3_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => SELECT SQL_CALC_FOUND_ROWS  wp_3_posts.ID FROM wp_3_posts  LEFT JOIN wp_3_term_relationships ON (wp_3_posts.ID = wp_3_term_relationships.object_id) INNER JOIN wp_3_postmeta ON ( wp_3_posts.ID = wp_3_postmeta.post_id ) WHERE 1=1  AND ( 
  wp_3_term_relationships.term_taxonomy_id IN (202)
) AND ( 
  wp_3_postmeta.meta_key = '_ilsi_date'
) AND wp_3_posts.post_type = 'publication' AND (wp_3_posts.post_status = 'publish') GROUP BY wp_3_posts.ID ORDER BY wp_3_postmeta.meta_value DESC LIMIT 0, 5
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 5877
                    [post_author] => 24
                    [post_date] => 2018-10-30 06:53:26
                    [post_date_gmt] => 2018-10-30 06:53:26
                    [post_content] => 
                    [post_title] => Understanding Mode of Action can Drive the Translational Pipeline Towards more Reliable Health Benefits for Probiotics
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => understanding-mode-of-action-can-drive-the-translational-pipeline-towards-more-reliable-health-benefits-for-probiotics
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2018-10-30 07:02:32
                    [post_modified_gmt] => 2018-10-30 07:02:32
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.eu/?post_type=publication&p=5877
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 3583
                    [post_author] => 24
                    [post_date] => 2017-01-26 08:05:47
                    [post_date_gmt] => 2017-01-26 08:05:47
                    [post_content] => 
                    [post_title] => Can Probiotics Modulate Human Disease by Impacting Intestinal Barrier Function?
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => can-probiotics-modulate-human-disease-by-impacting-intestinal-barrier-function
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-11-20 13:05:01
                    [post_modified_gmt] => 2017-11-20 13:05:01
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.eu/?post_type=publication&p=3583
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 3666
                    [post_author] => 24
                    [post_date] => 2017-03-16 08:50:42
                    [post_date_gmt] => 2017-03-16 08:50:42
                    [post_content] => 
                    [post_title] => Homeostasis of the Gut Barrier and Potential Biomarkers
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => homeostasis-of-the-gut-barrier-and-potential-biomarkers
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-11-20 13:19:01
                    [post_modified_gmt] => 2017-11-20 13:19:01
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.eu/?post_type=publication&p=3666
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 3337
                    [post_author] => 24
                    [post_date] => 2016-11-15 15:42:17
                    [post_date_gmt] => 2016-11-15 15:42:17
                    [post_content] => 
                    [post_title] => Human Intestinal Barrier Function in Health and Disease
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => human-intestinal-barrier-function-in-health-and-disease
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-11-20 13:23:59
                    [post_modified_gmt] => 2017-11-20 13:23:59
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.eu/?post_type=publication&p=3337
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 555
                    [post_author] => 12
                    [post_date] => 2016-05-10 10:32:04
                    [post_date_gmt] => 2016-05-10 10:32:04
                    [post_content] => 
                    [post_title] => Monitoring Immune Modulation by Nutrition in the General Population: Identifying and Substantiating Effects on Human Health
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => monitoring-immune-modulation-by-nutrition-in-the-general-population-identifying-and-substantiating-effects-on-human-health
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-11-20 13:25:56
                    [post_modified_gmt] => 2017-11-20 13:25:56
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://ilsi.org/europe/?post_type=publication&p=555
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 5
    [current_post] => -1
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 5877
            [post_author] => 24
            [post_date] => 2018-10-30 06:53:26
            [post_date_gmt] => 2018-10-30 06:53:26
            [post_content] => 
            [post_title] => Understanding Mode of Action can Drive the Translational Pipeline Towards more Reliable Health Benefits for Probiotics
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => understanding-mode-of-action-can-drive-the-translational-pipeline-towards-more-reliable-health-benefits-for-probiotics
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2018-10-30 07:02:32
            [post_modified_gmt] => 2018-10-30 07:02:32
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => http://ilsi.eu/?post_type=publication&p=5877
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 7
    [max_num_pages] => 2
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 1
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => a64e258284c602b4cad42baa22758482
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)