Joint Nutrition Cluster Activity on ‘Mechanistic Insights into the Gut-Brain Axis’

In collaboration with Early Nutrition and Long-Term Health; Health Benefits Assessment of Foods; Nutrition, Immunity & Inflammation; Nutrition & Brain Health; Prebiotics and Probiotics Task Forces

Background & Objectives

Currently, half of the literature available on the gut-brain axis is state-of-the-art reviews or correlative studies and comprehensive mechanistic insights underlining the bidirectional communication between the gut and the brain are lacking.
In this context, several Nutrition Task Forces decided to join forces to understand where we stand today regarding the mechanisms. Together the Task Forces will:

  • focus on translational aspects from pre-clinical to clinical studies;
  • focus on lifespan-related changes (but not disease related) in gut structure and function which play a role in long-term immune and brain health;
  • discuss the nutritional and lifestyle interventions with positive impact on the lifespan gut structure/function and thus on immune and brain health.

A workshop held in December 2019 brought together key experts from different fields of expertise to debate and discuss on the current knowledge and data gaps.
A perspective paper on this gap analysis is under construction. This publication will be followed by a series of web-seminars to discuss the identified gaps in more details.

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