Developing tools, guidance and supporting materials to scientifically substantiate health benefits of foods

Background

The determination of health benefits need to be supported by scientific evidence before being communicated via health or nutrition claims or other means.

Background

The Task Force expects to develop guidance and tools to define the scientific substantiation of benefits of foods and food constituents for maintenance and improvement of health and wellness. It also aims at identifying factors and compounds to help ensure health claims can meet regulatory standards.
Finally, the result will help understand the role of the microbiome in metabolising food constituents and mediating health benefits of foods.

Objectives

  • Develop guidance and tools to define the scientific substantiation of benefits of foods and food constituents for maintenance and improvement of health and wellness.
  • Identify factors and compounds to help ensure health claims can meet regulatory standards.
  • Help understand the role of the microbiome in metabolising food constituents and mediating health benefits of foods.

Impact

The Task Force, in conjunction with the recently completed Obesity & Diabetes Task Force, participated in the EUfunded project ‘Pivotal Assessment of the Effects of Bioactives on the Health and Wellbeing, from Human genome to Food Industry’.
The joint web-seminar ‘Microbial Metabolism Associated with Health’ was highlighted in the website of the EU’s joint Programming Initiative ‘A Healthy Diet for a Healthy Life’.
The Task Force has a track record of scientific publication with a significant number of citations and publication of guidelines that help stakeholders to perform high quality human intervention studies relating to foods.

For more detailed information, please contact Michela Miani at mmiani@ilsieurope.be  or Adam Coventry at acoventry@ilsieurope.be

Task Force Members


*Scientific Advisor

Expert Groups

Health benefits of polyphenols mediated by gut microbiome modulation and/or activity of microbial polyphenol-derived metabolites – New

Background & Objectives
Polyphenol consumption (present in dark berries, cocoa, nuts and others) has been associated with several cardiometabolic and cognitive function benefits. However, the mechanism of action is often not fully understood.
The objective is to better understand this mechanism, investigating the effects of consumption of food related polyphenols and microbial polyphenol-derived metabolites on the gut microbiome and associated health benefits.

Output
The resulting systematic review will give a better understanding of the mechanism of action and characterisation of the food related polyphenols, as well as the required dose for health benefits. This review may help to design future human intervention studies.

Review of the Evidence Base for Population Targeted Protein Intake for Muscle Health

Background & Objectives
Evidence shows that there is a strong link between nutrition and muscle health, particularly with regards to protein intake.
However, there are still open questions regarding the optimum protein intake depending on both physical activity and age. The Expert Group aims to answer this question; clarifying whether existing data for muscle health of those population groups differ.
Moreover, it will verify the impacts depending on the protein source (animal vs vegetal), which will help to better understand the implications of shifting to more plant-based and environmentally friendly diets without compromising muscle health.

Output
The Expert Group expects to deliver a peer-reviewed publication that will give a better understanding of the optimum protein intake, especially across potentially vulnerable target groups for muscle health.

Specific Guidelines for the Design and Conduct of Human Gut Microbiome Intervention Studies Relating to Foods – Completed


Background & Objectives

This Expert Group was set up to help design and execute human intervention studies to evaluate health benefits for food, focusing specifically on elements relevant for human gut microbiome studies.
The developed guidelines aim at supporting dietary recommendations to be built on solid scientific evidence regarding diet-gut microbiota/microbiome interactions.

Output

The resulting peer-reviewed publication includes guidelines that serve as scientific support to set up human intervention trials more comparable and reproducible.

Oral and Systemic Health Resilience

Background & Objectives

Evidence suggests that oral microbiome is a key factor in the prevalence and progression of gingivitis and periodontitis.
The Expert Group aimed at identifying the knowledge gaps and main influences on oral health homeostasis.
It also aimed at describing mechanisms contributing to experimental gingivitis.

Output

The findings will be included in two peer-reviewed publications, providing new insights into evidence relating to oral and systemic health.

Joint Nutrition Cluster Activity on ‘Mechanistic Insights into the Gut-Brain Axis’ In collaboration with Early Nutrition and Long-Term Health; Nutrition, Immunity & Inflammation; Nutrition & Brain Health; Prebiotics and Probiotics Task Forces – New

Background & Objectives

Currently, half of the literature available on the gut-brain axis is state-of-the-art reviews or correlative studies and comprehensive mechanistic insights underlining the bidirectional communication between the gut and the brain are lacking.
In this context, several Nutrition Task Forces decided to join forces to understand where we stand today regarding the mechanisms. Together the Task Forces will:

  • focus on translational aspects from pre-clinical to clinical studies;
  • focus on lifespan-related changes (but not diseaserelated) in gut structure and function which play a role in long-term immune and brain health;
  • discuss the nutritional and lifestyle interventions with positive impact on the lifespan gut structure/function and thus on immune and brain health.

Output

A workshop held in December 2019 brought together key experts from different fields of expertise to debate and discuss on the current knowledge and data gaps.
A perspective paper on this gap analysis is under construction. This publication will be followed by a series of web-seminars to discuss the identified gaps in more details.

Identifying Preferred Approaches for Quantifying the Impact of Modifying Nutrient Intakes

Background & Objectives

Public health authorities are developing programs to reduce or increase the nutritional composition of foods.
These programs are supported by a wide variety of models used to estimate the public health and economic impact of some nutrition interventions. However, these models use different methodologies so results may differ.
In consequence, comparing the models and its results is difficult.
The Expert Group aims at reviewing and evaluating these existing models and at providing recommendations on how to apply selected models.

Output

The results of the Expert Group’s evaluation are contained in a systematic review. Moreover, the Health Benefits Assessment of Foods Task Force organised the workshop ‘Identifying Preferred Approaches for Quantifying the Health and Economic Impact of Modifying Nutrient Intakes’ (6-7 April 2017, Brussels, Belgium).
The outcome of both the systematic review and the workshop will be submitted to a peer-reviewed journal.

Expert Group Members

Health benefits of polyphenols mediated by gut microbiome modulation and/or activity of microbial polyphenol-derived metabolites – New

Review of the Evidence Base for Population Targeted Protein Intake for Muscle Health

Specific Guidelines for the Design and Conduct of Human Gut Microbiome Intervention Studies Relating to Food – Completed

Oral and Systemic Health Resilience

Joint Nutrition Cluster Activity on ‘Mechanistic Insights into the Gut-Brain Axis’In collaboration with Early-Life and Long-Term Health; Health Benefits Assessment of Foods; Nutrition, Immunity & Inflammation; Nutrition & Mental Performance and Probiotics Task Forces – New

Identifying Preferred Approaches for Quantifying the Impact of Modifying Nutrient Intakes

Poster

ILSI Europe Marker Initiative: What Makes a Marker a Valid Marker?

Publications

All Publications

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => Functional Foods
            [authors] => 
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Functional Foods
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => Functional Foods
            [authors] => 
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Functional Foods
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
            [taxonomy] => ilsi_committee
            [term_id] => Functional Foods
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [terms] => Array
                                (
                                    [0] => Functional Foods
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_3_term_relationships
                )

            [queried_terms] => Array
                (
                    [ilsi_committee] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => Functional Foods
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_3_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_3_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_3_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_3_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_3_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_3_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => SELECT SQL_CALC_FOUND_ROWS  wp_3_posts.ID FROM wp_3_posts  LEFT JOIN wp_3_term_relationships ON (wp_3_posts.ID = wp_3_term_relationships.object_id) INNER JOIN wp_3_postmeta ON ( wp_3_posts.ID = wp_3_postmeta.post_id ) WHERE 1=1  AND ( 
  wp_3_term_relationships.term_taxonomy_id IN (67)
) AND ( 
  wp_3_postmeta.meta_key = '_ilsi_date'
) AND wp_3_posts.post_type = 'publication' AND (wp_3_posts.post_status = 'publish' OR wp_3_posts.post_status = 'acf-disabled') GROUP BY wp_3_posts.ID ORDER BY wp_3_postmeta.meta_value DESC LIMIT 0, 5
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 7714
                    [post_author] => 204
                    [post_date] => 2020-05-12 11:50:33
                    [post_date_gmt] => 2020-05-12 11:50:33
                    [post_content] => 
                    [post_title] => Considerations for the design and conduct of human gut microbiota intervention studies relating to foods.
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => considerations-for-the-design-and-conduct-of-human-gut-microbiota-intervention-studies-relating-to-foods
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2020-05-12 11:57:52
                    [post_modified_gmt] => 2020-05-12 11:57:52
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://ilsi.eu/?post_type=publication&p=7714
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 6766
                    [post_author] => 24
                    [post_date] => 2019-09-16 11:24:42
                    [post_date_gmt] => 2019-09-16 11:24:42
                    [post_content] => 
                    [post_title] => Resistance and Resilience to Experimental Gingivitis: a Systematic Scoping Review
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => resistance-and-resilience-to-experimental-gingivitis-a-systematic-scoping-review
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2019-09-16 11:25:41
                    [post_modified_gmt] => 2019-09-16 11:25:41
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://ilsi.eu/?post_type=publication&p=6766
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 4868
                    [post_author] => 24
                    [post_date] => 2017-11-08 13:38:04
                    [post_date_gmt] => 2017-11-08 13:38:04
                    [post_content] => 
                    [post_title] => Systematic Review of the Effects of the Intestinal Microbiota on Selected Nutrients and Non-Nutrients
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => systematic-review-of-the-effects-of-the-intestinal-microbiota-on-selected-nutrients-and-non-nutrients
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2018-03-01 13:53:18
                    [post_modified_gmt] => 2018-03-01 13:53:18
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.eu/?post_type=publication&p=4868
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 3969
                    [post_author] => 24
                    [post_date] => 2017-04-14 06:05:27
                    [post_date_gmt] => 2017-04-14 06:05:27
                    [post_content] => 
                    [post_title] => Gut Microbiota Functions: Metabolism of Nutrients and other Food Components
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => gut-microbiota-functions-metabolism-of-nutrients-and-other-food-components
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2018-03-01 13:38:13
                    [post_modified_gmt] => 2018-03-01 13:38:13
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.eu/?post_type=publication&p=3969
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 3649
                    [post_author] => 24
                    [post_date] => 2017-03-08 14:33:12
                    [post_date_gmt] => 2017-03-08 14:33:12
                    [post_content] => 
                    [post_title] => Improving selection of markers in nutrition research: evaluation of the criteria proposed by the ILSI Europe Marker Validation Initiative
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => improving-selection-of-markers-in-nutrition-research-evaluation-of-the-criteria-proposed-by-the-ilsi-europe-marker-validation-initiative
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-03-20 08:23:36
                    [post_modified_gmt] => 2017-03-20 08:23:36
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.eu/?post_type=publication&p=3649
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 5
    [current_post] => -1
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 7714
            [post_author] => 204
            [post_date] => 2020-05-12 11:50:33
            [post_date_gmt] => 2020-05-12 11:50:33
            [post_content] => 
            [post_title] => Considerations for the design and conduct of human gut microbiota intervention studies relating to foods.
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => considerations-for-the-design-and-conduct-of-human-gut-microbiota-intervention-studies-relating-to-foods
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2020-05-12 11:57:52
            [post_modified_gmt] => 2020-05-12 11:57:52
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://ilsi.eu/?post_type=publication&p=7714
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 11
    [max_num_pages] => 3
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 1
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => f967d2fef6c71b6831490200ee0d01b2
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)