Determining reliable markers for nutritional modulation of immune function and inflammation

Background

A well-functioning immune system is essential for human health and wellbeing. Nutrition plays a major role in shaping and optimising immune functions.

Objectives

This task force focuses on better understanding the impact of nutrition on immune functions and on determining reliable markers of immuno-modulation and inflammation, relevant to health and well-being. In the context of health claims regulation, the task force provides guidance for the design, assessment and interpretation of nutritional intervention studies that intend to modulate immune functions.

Impact

Peer-reviewed guidance documents on marker selection and interpretation have been produced by multiple expert groups from this task force. The use of common reliable markers in different studies facilitates data comparison and strengthens the evidence in nutrition and immunity.

This work is valuable for the design of nutrition interventions evaluating effects of foods and food components on immune functions, being thus useful for researchers struggling to scientifically substantiate immune-related health effects.

The latest publication (R. Albers et al., 2013) focuses on immunomodulation and had several thousands of full text views. It describes how to select immune markers for future trials and provides a framework for the interpretation of outcomes. A number of inflammatory challenges reflecting metabolic stress, infection and tissue damage have been described in P.C. Calder et al., 2013. Using multiple markers and dynamics of response is recommended and the application of standardised methods is outlined.

What’s New

  • An upcoming activity in 2017/2018 on ‘Quality of Life Measure as a Marker of Infections’ will review and evaluate the relevance and level of validation of quality of life measures. The goal is to reach an expert consensus on the usefulness of quality of life assessments as an indicator of common infections in the population.
  • The task force members also intend to explore areas at the crossroads between nutrition and medicine. Two aspects might be considered, (i) examining how nutrition reduces the side effects of medical treatments in general; (ii) developing a review on how nutrition affects the response to vaccination.

For more detailed information, please contact Dr Tobias Recker at trecker@ilsieurope.be.

Task Force Members

Dr Jalil Benyacoub – Chair Nestlé CH
Dr Anita Hartog – Vice Chair Danone NL
Prof. Philip Calder – Co-Chair University of Southampton UK
Dr Stein-Erik Birkeland Tine R&D NO
Dr Patrizia Bohnhorst Merck Consumer Health DE
Dr Dianne Delsing FrieslandCampina NL
Dr Markus Lehtinen DuPont Nutrition and Health FI
Dr Tobias Recker ILSI Europe BE

Expert Groups

Immune Competence Across Lifespan: Impact of Nutrition on Immune Competence and its Consequences Later in Life

Objectives

While the importance of a well-functioning immune system is recognised, the critical nutrients supporting optimal immune development in the first years of life as well as the impact of early life nutrition on later life immune competence are still under debate. This activity is intended to explore first the interaction between nutrition and immune competence in early life. Markers relevant for health should be identified. Building on these markers, the influence of early life nutrition on health later in life will be evaluated in a second step.

Activity

Two multidisciplinary expert panels will review and define the state-of-the art on the following subjects:

  • Activity A: Key markers of immune competence early in life will be determined, as well as the impact of nutrition on these.
  • Activity B: This activity is correlated with Activity A. Not only will the experts build on the results of Activity A, but this activity will also review the impact of early life immune competence on health trajectory later in life with an emphasis on assessing the impact of early nutrition on later life immunity.
  • It is intended to organise a workshop before submission of the manuscripts with an enlarged panel of multidisciplinary experts including the expert panels from activity A and B to build interaction between the two groups and to further forge connections between the two activities.

Expected Output

The output of this activity is expected to be published in a peer-reviewed journal. The outcomes will provide health-care professionals with a recommendation of readouts for immune competence and nutritional recommendations for an optimal performing immune system early in life. It will further draw associations between early life nutrition and immune competence later in life.

Health Relevance of the Modification of Low-grade Inflammation in Ageing: Causes, Effects and Health & Wellbeing Consequences of LGI

Objectives

Low-grade inflammation (LGI) is characterised by levels of inflammatory markers slightly above ‘normal’. LGI has been linked to several chronic adverse health conditions including obesity, metabolic syndrome and cardiovascular diseases. It also occurs as a natural consequence of ageing. However, its relevance for several disease conditions is not clear. Moreover, it is not yet clarified if a reduction of LGI is really needed in optimising health in ageing. The aim of this project is to clarify if a modification in LGI could have a beneficial effect. Do strategies in reducing inflammation support or impair host defence? The project differs from previous activities as it does not start from a pathological viewpoint and, hence, does not generally consider a modification in the inflammatory response as positive treatment.

Activity

The review highlights the health relevance of modifying LGI in terms of well-being and health. The experts focused more on the modifiers (such as nutrition and lifestyle factors) than on the triggers of LGI. Since the gut-brain axis seems to be a central component in the modulation of LGI, the review addresses the cross-talk between the gut and the brain. In addition, the manuscript covers the interaction between liver, adipose tissue, skeletal muscle and additional body compartments in LGI condition. The review is almost ready for submission.

Expected Output

This paper provides recommendations for future (clinical) studies on LGI. These recommendations should help clarify how a modulation of LGI affects immune functions in the host and may benefit health. It could serve as a basis for facilitating the design and interpretation of research and could provide support for the development of health claims on food.

Expert Group Members

Immune Competence Across Lifespan: Impact of Nutrition on Immune Competence and its Consequences Later in Life

The composition of the Immune Competence Across Lifespan: Impact of Nutrition on Immune Competence and Its Consequences Later in Life Expert Group will be listed as soon as it is confirmed.

Health Relevance of the Modification of Low-grade Inflammation in Ageing: Causes, Effects and Health & Wellbeing Consequences of LGI

Prof. Philip Calder University of Southampton UK
Dr Nabil Bosco – Vice-Chair Nestlé CH
Dr Patrizia Bohnhorst Merck Consumer Healthcare DE
Dr Raphaëlle Bourdet-Sicard Danone FR
Dr Lucille Capuron National Institute of Agricultural Research (INRA) FR
Prof. Nathalie Delzenne Université Catholique de Louvain BE
Dr Joël Doré National Institute of Agricultural Research (INRA) FR
Prof. Claudio Franceschi University of Bologna IT
Dr Francesco Visioli Mardrid Institute of Advanced Studies (IMDEA)-Food ES
Dr Tobias Recker ILSI Europe BE

 

Poster

Monitoring Immune Modulation by Nutrition in the General Population: Identifying and Substantiating Health Effects

Publications

All Publications

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => Nutrition and Immunity
            [authors] => 
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Nutrition and Immunity
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => Nutrition and Immunity
            [authors] => 
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Nutrition and Immunity
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [static] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
            [taxonomy] => ilsi_committee
            [term_id] => Nutrition and Immunity
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [terms] => Array
                                (
                                    [0] => Nutrition and Immunity
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_3_term_relationships
                )

            [queried_terms] => Array
                (
                    [ilsi_committee] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => Nutrition and Immunity
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_3_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_3_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_3_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_3_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_3_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [alias] => wp_3_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => SELECT SQL_CALC_FOUND_ROWS  wp_3_posts.ID FROM wp_3_posts  LEFT JOIN wp_3_term_relationships ON (wp_3_posts.ID = wp_3_term_relationships.object_id) INNER JOIN wp_3_postmeta ON ( wp_3_posts.ID = wp_3_postmeta.post_id ) WHERE 1=1  AND ( 
  wp_3_term_relationships.term_taxonomy_id IN (154)
) AND ( 
  wp_3_postmeta.meta_key = '_ilsi_date'
) AND wp_3_posts.post_type = 'publication' AND (wp_3_posts.post_status = 'publish') GROUP BY wp_3_posts.ID ORDER BY wp_3_postmeta.meta_value DESC LIMIT 0, 5
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 523
                    [post_author] => 12
                    [post_date] => 2016-05-08 19:40:21
                    [post_date_gmt] => 2016-05-08 19:40:21
                    [post_content] => 
                    [post_title] => A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => a-consideration-of-biomarkers-to-be-used-for-evaluation-of-inflammation-in-human-nutritional-studies
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-22 18:23:41
                    [post_modified_gmt] => 2016-06-22 18:23:41
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/europe/?post_type=publication&p=523
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 555
                    [post_author] => 12
                    [post_date] => 2016-05-10 10:32:04
                    [post_date_gmt] => 2016-05-10 10:32:04
                    [post_content] => 
                    [post_title] => Monitoring Immune Modulation by Nutrition in the General Population: Identifying and Substantiating Effects on Human Health
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => monitoring-immune-modulation-by-nutrition-in-the-general-population-identifying-and-substantiating-effects-on-human-health
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-20 17:10:13
                    [post_modified_gmt] => 2016-06-20 17:10:13
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/europe/?post_type=publication&p=555
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 1715
                    [post_author] => 12
                    [post_date] => 2016-06-18 02:54:59
                    [post_date_gmt] => 2016-06-18 02:54:59
                    [post_content] => 
                    [post_title] => Nutrition and Immunity in Man, 2nd Edition
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => nutrition-and-immunity-in-man-2nd-edition
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-08-16 13:46:57
                    [post_modified_gmt] => 2016-08-16 13:46:57
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.eu/?post_type=publication&p=1715
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 3
    [current_post] => -1
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 523
            [post_author] => 12
            [post_date] => 2016-05-08 19:40:21
            [post_date_gmt] => 2016-05-08 19:40:21
            [post_content] => 
            [post_title] => A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => a-consideration-of-biomarkers-to-be-used-for-evaluation-of-inflammation-in-human-nutritional-studies
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2016-06-22 18:23:41
            [post_modified_gmt] => 2016-06-22 18:23:41
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => http://ilsi.org/europe/?post_type=publication&p=523
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 3
    [max_num_pages] => 1
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 1
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 3e4d6ec519638ca4226f896e9a02bcf0
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)