Exploring new toxicological safety assessment technologies for the food industry

Strategic Vision

The task force lays the groundwork for researchers interested in the advances in food safety assessment.

Background

The application of new tools in assessment of toxicology in food area is not always straightforward as those tools are not designed to measure toxicity per se. The task force aims to be at the forefront on the progress on food safety assessment to contribute towards safe food ingredients.

Objectives

  • Investigate how new approaches can be applied in risk assessment relevant to the development of safe food and food ingredients.
  • Propose guidance on the utility, development and application of novel methodologies to assess hazard and risk in the food chain.

Achieved Results

  • The task force organised the workshop ‘The Use of AOPs in Safety Evaluation of Food Additives’ on 26-27 February 2018 in Brussels, BE, which was an opportunity to discuss the potential use of AOPs for hazard identification, risk and safety assessment of food additives.
  • The task force has an accepted manuscript (Kramer et al. 2019, ‘Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs’) and three more are going to be submitted by the end of 2019.

Scientific Impact

  • The results of the task force are well disseminated in a wide range of international meetings and congresses (ESTIV, EUROTOX).
  • The publications on ‘Considering New Methodologies in Strategies for Safety Assessment of Foods and Food Ingredients’ (B.J. Blaauboer et al., 2016) has received over 24 citations.

For more detailed information, please contact Angeliki Stavropoulou at astavropoulou@ilsieurope.be or Belinda Antonio at bantonio@ilsieurope.be.

Task Force Members

Expert Group

Application of Adverse Outcome Pathways (AOPs) for Foods and Food Ingredients in Risk Assessment NEW

Background & Objectives

  • Explore the potential role of AOPs for safety evaluation in the food area.
  • Understand the coverage of existing AOPs for food ingredients / food additives.
  • Identify the necessary additional information required to enable AOPs to be implemented for quantitative risk assessment and regulatory use to support the shift from animal testing to non-animal approaches in food safety risk assessment.

Output

  • The outcome of the activity is expected to provide guidance for industry and risk assessors in the food sector to maximise the utilisation of emerging toxicological science that is more human relevant and less animal-dependent.
  • The group has a first peer-reviewed publication that provides insights in coverage of critical effects of food additives by AOPs.
  • A second peer-reviewed publication is going to be submitted by fall 2019, concerning the application of existing AOPs in safety evaluation of food additives.

Exploitation of ToxCast Data on Food Chemicals for Safety Risk Assessment

Background & Objectives
ToxCast chemicals have been reviewed and clustered into groupings of similar chemicals according to functional and structural characteristics.

Associations between groupings and toxicological profiles observed in ToxCast assays may have implications for risk assessment.

Explores opportunities to understand how ToxCast21 data and methods could be used in safety risk assessment for foods.

This activity aims to contribute to the development of alternative approaches for safety assessments in food industry.

Output
This activity is expected to deliver two manuscripts on the use of ToxCast data in the safety evaluation of food chemicals.

You can find the direct link to the first publication here.

Expert Group Members

Application of Adverse Outcome Pathways (AOPs) for Foods and Food Ingredients in Risk Assessment? NEW

Exploitation of ToxCast Data on Food Chemicals for Safety Risk Assessment

Publications

All Publications

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