Providing guidance on microbial issues for efficient food safety systems

Strategic Vision

The task force identifies emerging research gaps in food microbiology and addresses possible measures to tackle such gaps.

Background

Factors such as climate, global trade, the usage of new ingredients and consumer behaviours might affect microbial populations in food. Therefore, a more conceptual framework detailing how to incorporate risk analyses in food safety management systems is needed.

Objectives

  • Facilitate the development of harmonised, science-based approaches to predict and prevent risks, supporting dialogue for decision-making by regulators and food industry.
  • Review the existing knowledge on current and (re-)emerging pathogen behaviour and ecology and identify reasons why they persist (e.g. detection and typing methods, as well as potential control options available).

Achieved Results

  • The expert group on Next Generation Sequencing (Jagadeesan et al., 2019) was recently published in Food Microbiology.
  • The expert group on Foodborne viruses (Bosch et al., 2018) was published in the International Journal of Food Microbiology and was presented during a roundtable at the 2019 International Association for Food Protection (IAFP) European Symposium on Food Safety.

Scientific Impact

The Task Force frequently collaborates with the IAFP and has been actively involved at both an organizing level through dissemination activities and producing peer-reviewed publications through their Professional Developmental Groups.

Ongoing

An ongoing activity on ‘Parameters for Process Validation Study Protocols’ is being finalised. Food manufacturers and processors are required to obtain scientific evidence that a control measure or combination of control measures, if properly implemented, is capable of controlling a hazard to a specified outcome. However, there are no generic protocols available that could guide manufacturers and ensure that all relevant aspects are considered, when undertaking a validation. Therefore, the task force is currently developing a recommended protocol for validation studies in order to control foodborne pathogens.

The task force is currently considering potential new activities and would welcome your contribution on the following topics:

  • Environmental Monitoring Guidelines/ Control Programs (best practice);
  • Industrial Microbiological Risk Assessment in Dairy Products;
  • The Use of Meta-Analysis in Microbiological Risk Assessments;
  • Pathogens of Relevance (STEC and Listeria) in Low Moisture Food;
  • When do Spoilage Organisms become a Food Safety Issue?

What’s New

The Special Issue on ‘Omics in MRA – the Integration of Omics in Microbiological Risk Assessment’ was a joint effort by ILSI Europe, IAFP and ICFMH in the International Journal of Food Microbiology. The results of this special issue will be featured in a webinar on 27 March 2019.

The task force has published a paper on ‘The Use of Next Generation Sequencing for Improving Food Safety: Translation into Practice’, in Food Microbiology (B. Jagadeesan et al., 2018). The expert group presented their work and recommendations in a roundtable discussion at the IAFP European Symposium 2018 in Stockholm, Sweden on 25 April 2018.

The task force has published a paper on ‘Foodborne Viruses: Detection, Risk Assessment, and Control Options in Food Processing’, in International Journal of Food Microbiology (A. Bosch et al., 2018). The expert group will present their work and recommendations in a roundtable discussion at the IAFP European Symposium 2019 in Nantes, France on 25 April 2019.

Objectives

By investigating microbial issues in foods that are related to public health risks, this task force facilitates the development of and raises awareness of harmonised, science-based approaches to predict and prevent risks, supporting an international dialogue for decision-making by regulators and food industry. The task force critically reviews the existing knowledge on pathogen behaviour and ecology and why they persist (e.g. detection and typing methods, as well as potential control options available). Research gaps are also being identified, thereby stimulating further research activities.
The task force assesses (re-)emerging micro-organisms to address potential issues, before they would become an incidence. Such insights are very useful in guidance for the food industry and could also be considered by regulatory bodies, when performing their risk assessments.

Impact

  • The task force is continuously working on guidance documents for authorities, small and medium businesses (also suppliers) to support them in implementing efficient food safety systems, e.g. on microbial risk assessment and verification testing.
  • Over 450 people attended a free live webinar on the ‘Relevance of End-Product Testing in Food Safety Management’, organised in partnership with the International Association for Food Protection (IAFP). The webinar presented findings from two recent publications (M.H. Zwietering et al., 2016; R. Buchanan & D. Schaffner, 2015). The ILSI Europe publication was downloaded over 6,500 times and has received over 19,000 views on Mendeley.
  • This task force has a long standing history of being involved in the organising committee of IAFP’s European Symposium on Food Safety and has been organising scientific sessions at the symposium for years. This year the task force supported multiple sessions at IAFP’s European Symposium on Food Safety 2017 (29-31 March 2017, Brussels, Belgium) and IAFP’s Annual Meeting (9-12 July 2017, Tampa, US) and was leading the Local Organising Committee at the European symposium.
  • Our report on ‘Persistence and Survival of Pathogens in Dry Food Processing Environments’ (L. Beuchat et al., 2011) served as a basis for a paper Low–Water Activity Foods: Increased Concern as Vehicles of Foodborne Pathogens (L. Beuchat et al., 2013) which was awarded the 2016 Most-Downloaded Journal of Food Protection Publication Award.

For more detailed information, please contact Angeliki Stavropoulou at astavropoulou@ilsieurope.be or Toula Aslanidis at taslanidis@ilsieurope.be

Task Force Members

*Scientific Advisor

Expert Groups

Environmental Monitoring in Dry production environments – Are we looking for the right thing(s) / microorganism? – New

Background & Objectives
Environmental monitoring (EM) programs are gaining increasing importance in the context of food safety plans / HACCP programs, since past outbreaks have shown the relevance of the environment to ensure the safety of products. However, there are still many open questions and unclarity to how to set up a meaningful program, which would provide early warnings of potential product contamination.

Output
The current activity aims to evaluate existing scientific information on microorganisms of importance and / or concern in dry production environments. That would then help industry and regulators to focus and set up targeted EM programs depending on their purpose.

Process Validation Study Protocols for Control Measures of Foodborne Pathogens in Foods – Ongoing

Background & Objectives
Up to date there are no generic protocols available that could guide manufacturers and ensure that all relevant aspects are considered when undertaking a validation. To tackle this, the expert group aims to develop a recommended protocol for validations studies to control foodborne pathogens in various food matrices.

Output
The resulting publication will help to establish an industry wide standard protocol to validate the Critical Control Points (CCP) in the HACCP (Hazard Analysis Critical Control Point) plan. It will eliminate or reduce the variation issues among food safety professionals, consultants and third party laboratories to conduct a validation study. The output would especially support small and medium size businesses that have fewer resources to those tasks available. It would also improve the overall understanding of validations processes in practice.

The Use Of Next-Generation Sequencing (NGS): Translation into Practice – Completed

Objectives
Next Generation Sequencing (NGS) tools are fast evolving techniques that are already applied in many different fields spanning from epidemiology, outbreak investigations, anti-microbial resistance, ecology and evolution of microorganisms. However, there is a lack of communication and understanding on how NGS tools are being used and interpreted by regulators to investigate food safety incidents. Knowledge gaps exist regarding the application of NGS in the food microbiology area. It is imperative for all parties involved to understand NGS and its current limitations and to have guidelines on how it could be implemented and used to improve food safety. Although there are reports on the use of metagenomics tools to study microbial ecology in food or the food associated environment, the application of these tools to improve the food safety risk assessment/management options has yet to be investigated. Based on the above, the expert group will address some of the questions triggered by the NGS technologies, such as best practices to be considered during data generation, data analysis, and it will also explore the possibilities of data sharing amongst all stakeholders for the overall improvement of food safety.

Activity
This activity has two main aims:

  • To investigate how NGS applications / research of food and food associated environmental microbial community can contribute to the improvement of risk assessment and risk management options;
  • To provide guidance to industry describing values and current limitations on generation of sequence information, bioinformatics analyses and biological interpretation of data employed in NGS analysis.

With the support of ILSI Japan, ILSI North America and ILSI Southeast Asia Region, this activity is tackled at a global scale.

Expected Output
The activity will result in a peer-reviewed publication discussing the potential uses and data gaps in the field on NGS. Additionally, a separate guidance document on NGS will bring clarity on how the tools can be implemented and their potential applications for the improvement of food safety. As some NGS tools are still in the early stages, this expert group will help steer the research to exploit the full potential of using NGS tools. The final output will improve the industry knowledge and will ultimately contribute to the advancement of public health by improving food safety.

Control Options for Viruses in Food Processing – Completed

Objectives
Viruses occur frequently and are probably the most under-recognised cause of foodborne illnesses. Unfortunately, viruses are quite resistant to many treatments used in food processing and could also contaminate food via their occurrence in the production/processing environment. The purpose of this activity is to review current knowledge on how viruses can be controlled in food-industrial settings.

Activity
The experts are discussing and summarising the control options for viruses in different food processing systems. Data/knowledge gaps that need to be considered in order to determine specific performance objectives for viruses in foods will then be evaluated. In addition, the experts will provide recommendations for further research including specific processing technologies (e.g. heat treatment, but also non-thermal treatments and their effects on viruses) and methodological considerations (e.g. limitations, design and drawbacks of inactivation studies or the use of surrogate viruses).

Expected Output
The manuscript on ‘Foodborne Viruses: Detection, Risk Assessment, and Control Options in Food Processing’ has been submitted for publication. It features foodborne viruses that contribute to their potential as foodborne disease agents, focusing primarily on norovirus, hepatitis A and E viruses. Also, it studies their epidemiology, their methodological considerations, and assesses natural persistence, foods at risk and procedural technologies. Furthermore, the publication will highlight data gaps and challenges in experimental design and processing technologies. Ultimately, this publication will pave the way forward to establish specific performance objectives that could serve as references for food producers, food regulators and for risk assessment.

Industrial Microbiological Risk Assessment (MRA) – Completed

Phase 1 – Fresh Produce
Objectives
There is a lack of practical, applicable data and guidelines to perform Microbiological Risk Assessment (MRA). The information that currently exists in the public domain is highly theoretical and very generic; applying it to different industry sectors can be difficult. The activity aims to provide easy-to-follow and practical MRA recommendations specific to different industry sectors and guidance on the implementation of risk assessment strategies within companies.

Activity
Existing risk assessment tools are used to develop a series of publications directed towards several food sectors explaining the different approaches to MRA with examples. This guidance will help the reader gain an understanding of and hence apply risk assessment to the sector in focus.

Output
The first activity of this expert group focused on fresh produce to be consumed uncooked. This example was chosen since a significant reduction in microbial load is difficult to achieve. This paper proposes an approach based on a structured qualitative assessment, which requires all decisions to be based on evidence and on a framework for describing the decision process that can be challenged and defended within the supply chain. In addition, the paper highlights the need for evidence bases to be more easily available and accessible to primary producers and identifies the need to develop hygiene criteria to aid validation of proposed interventions.

As a follow-up, a series of publications supporting a wide range of industry sectors (e.g. first dairy, and subsequently ready-to-eat meal, meat, poultry, fish, seafood) in understanding and applying risk assessment to their specific processes will be envisaged. Ultimately, these publications should lead to safer food for the consumer.

Expert Group Members

Environmental Monitoring in Dry production environments – Are we looking for the right thing(s) / microorganism? – New

Process Validation Study Protocols for Control Measures of Foodborne Pathogens in Foods – Ongoing

The Use Of Next-Generation Sequencing (NGS): Translation into Practice – Completed

* The participation of these experts is supported by ILSI Japan, ILSI North America or ILSI Southeast Asia Region.
**This company is a member of ILSI Japan.

Control Options for Viruses in Food Processing – Completed

Industrial Microbiological Risk Assessment (MRA)

Publications

The task force organised a webinar designed for industry experts and regulatory agencies on the relevance of end-product testing in food safety management, on November 2015, with the support of IAFP.’

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