British Journal of Nutrition. 2008;99(Suppl 2):S1-S46
This report provides a description and insights into some of the factors and data requirements that must be assessed and evaluated in the context of a risk-benefit analysis of the mitigation measures that may be under consideration for the reduction of acrylamide levels in three example commodities. The potential effect of mitigation measures on the overall MOE was assessed by modelling different exposure scenarios. The relatively small impact of the selected potential mitigation measures on the overall MOE was highlighted especially for high intake consumers. In case of simultaneous exposure to more than one compound as a result of a mitigation measure, there is a need to balance these potential risks v. the risk of potential acrylamide exposure. In this respect, the usefulness of a simultaneous exposure model as a potential tool for acrylamide risk-benefit analysis was demonstrated.
Uncertainties in the limited available information, data and gaps in the current knowledge were also identified.
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