Journal of Nutrition. 2011;141:989S-1009S
Evidence of beneficial health effects of polyphenols in the prevention of cancers and cardiovascular and neurodegenerative diseases is growing. Polyphenols are thought to modulate not only oxidative stress but also several other specific biological pathways, such as the ability to modulate the activity of many enzymes and cell receptors. However, this is an area that needs further research.
The objective of this expert group was to apply the PASSCLAIM criteria to provide the scientific substantiation of a polyphenol claim. While PASSCLAIM was a theoretical exercise, this activity tested the criteria to re-assess the tool and applicability of the criteria to substantiate a claim using polyphenols as an example.
The addressed topics would include:
- Effective dose and evidence for the effects of polyphenol consumption on health;
- Concept to calculate minimum amounts necessary to cause health benefit;
- Reference in vitro test and validated reference method to measure efficacy/amount of polyphenols in food;
- Relevance of bioavailability and fate of metabolites, including effect of food matrix, polyphenol formulation and interference with other components;
- Best practice for human study design to assess bioequivalence of polyphenols for bioavailability and for providing scientific substantiation of claims based on polyphenols;
- Associations between polyphenols and benefits for human health with a grading of evidence.
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