Are Current Analytical Methods Suitable to Verify VITAL® 2.0/3.0 Allergen Reference Doses for EU Allergens in Foods?

Food allergy affects up to 6% of Europeans. Allergen identification is important for the risk assessment and management of the inadvertent presence of allergens in foods. The VITAL® initiative for voluntary incidental trace allergen labeling suggests protein reference doses, based on clinical reactivity in food challenge studies, at or below which voluntary labelling is unnecessary. Can current analytical methodology verify the published VITAL® 2.0 doses in serving sizes between 5 and 500 g? To answer this question the expert group reviewed available data on published and commercial ELISA, PCR and mass spectrometry methods, especially for the detection of peanuts, soy, hazelnut, wheat, cow’s milk and hen’s egg.

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