Food and Chemical Toxicology. 2010;48(Suppl 1):S1-S111
This series of papers presents the work of an expert group established by ILSI Europe to follow up the recommendations of an international conference on ‘‘Risk Assessment of Compounds that are both Genotoxic and Carcinogenic: New Approaches”. Twelve genotoxic and carcinogenic chemicals that can be present in food were selected for calculation of a Margin of Exposure (MOE) between a point of departure on the dose–response for oral carcinogenicity in animal studies and estimates of human dietary exposure.
The MOE can be used to support prioritisation of risk management action and, if the MOE is very large, on communication of a low level of human health concern. Depending on the approaches taken in determining the point of departure and the estimation of exposure, it is possible to derive very different values for the MOE. It is therefore essential that the selection of the cancer endpoint and mathematical treatment of the data are clearly described and justified if the results of the MOE approach are to be trusted and of value to risk managers. An outline framework for calculating an MOE is proposed in order to help to ensure transparency in the results.
The following files can be downloaded:
Case studies:
- Acrylamide
- Aflatoxin B1*
- Benzo[a]pyrene and polycyclic aromatic hydrocarbons*
- Benzene
- 1,3-Dichloro-2-propanol (DCP)
- Ethyl carbamate
- Furan
- Leucomalachite green
- 1-Methylcyclopropene and its impurities (1-chloro-2-methylpropene and 3-chloro-2-methylpropene)
- Methyleugenol
- PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)
- Sudan I
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To order free copies of the supplement: publications@ilsieurope.be.