Roles and Applications of in Vitro Bioassays in Safety Evaluation of Food Contact Materials

Background & Objectives

There is an urgent need to better understand the actual safety significance of food contact materials (FCM) as a source of chemical exposure in humans. In vitro bioassays may play a role in the assessment of complex mixtures of chemicals migrating from FCM.

The objective of the activity is to review the roles, availability and suitability of in vitro bioassays for safety assessment of FCM.


The outputs of this activity were reviewed at a workshop held on 8-9 November 2018 in Brussels, BE, to discuss the most relevant bioassays, their limitations and relevance in the context of packaging safety. This output will allow us to develop and publish a transparent guidance document on the use of in vitro data in packaging safety assessment.