Advances in Nutrition, 2022
Commissioned by the Prebiotics and Probiotics Task Forces.
British Journal of Nutrition 2013; 110(2):S1-S30. Commissioned by the Nutrition and Immunity and Probiotics Task Forces.
This perspective examines how pregnancy-related microbial shifts, both natural andprobiotic-induced, affect maternal and fetal health and highlights potential opportunities for theinnovative use of probiotics during the gestation period
Clinical and Translational Gastroenterology 2016. 7, e196. Commissioned by the Probiotics Task Force.
American Journal of Physiology – Gastrointestinal and Liver Physiology 2017; 312 (3): G171-G193. Commissioned by the Probiotics Task Force.
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Humans often show variable responses to dietary, prebiotic, and probiotic interventions. Emerging evidence indicates that the gut microbiota is a key determinant for this population heterogeneity. Here, we provide an overview of some of the major computational and experimental tools being applied to critical questions of microbiota-mediated personalized nutrition and health. First, we discuss the latest advances in in silico modeling of the microbiota-nutrition-health axis, including the application of statistical, mechanistic, and hybrid artificial intelligence models. Second, we address high-throughput in vitro techniques for assessing inter-individual heterogeneity, from ex vivo batch culturing of stool and continuous culturing in anaerobic bioreactors, to more sophisticated organ-on-a-chip models that integrate both host and microbial compartments. Third, we explore in vivo approaches for better understanding personalized, microbiota-mediated responses to diet, prebiotics, and probiotics, from non-human animal models and human observational studies, to human feeding trials and crossover interventions. We highlight examples of existing, consumer-facing precision nutrition platforms that are currently leveraging the gut microbiota. Furthermore, we discuss how the integration of a broader set of the tools and techniques described in this piece can generate the data necessary to support a greater diversity of precision nutrition strategies. Finally, we present a vision of a precision nutrition and healthcare future, which leverages the gut microbiota to design effective, individual-specific interventions.
Download the full article here
or click on the image below to download the one-pager summary.
Commissioned by the Prebiotics and Probiotics Task Forces.
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[post_title] => Monitoring Immune Modulation by Nutrition in the General Population: Identifying and Substantiating Effects on Human Health
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Abstract
Pregnancy induces notable alterations in the gut, vaginal, and oral microbiota driven by hormonal,immune, metabolic, dietary, and environmental factors. During pregnancy, the gut microbiota ischaracterized by increased proportions of the genus Bifidobacterium and the phylaPseudomonadota (formerly Proteobacteria) and Actinomycetota (formerly Actinobacteria). Thesechanges occur alongside reduced alpha diversity and greater beta diversity, changes that influencematernal metabolism and fetal development. Shifts in gut and oral microbiota have been asso-ciated with complications such as preterm birth (PTB), pre-eclampsia, and gestational diabetes(GDM), though patterns are sometimes inconsistent. The vaginal microbiota remains Lactobacillus-dominant during pregnancy, with reduced diversity leading to reduced risk of pathogenic infectionand increased diversity has been linked with a higher risk of PTB. Hormonal changes also affect theoral microbiota, potentially increasing pathogenic species and contributing to adverse outcomeslike PTB. Probiotic supplementation during pregnancy has significant potential to reduce adversepregnancy outcomes; however, clinical studies are still limited. Probiotics may be effective inalleviating maternal constipation and lead to lower PTB risk, particularly by modulating the vaginalmicrobiota, but they have limited impact on GDM. In the context of maternal mental health, somestudies suggest benefits of probiotics in reducing anxiety, but effects on depression are incon-clusive. This perspective examines how pregnancy-related microbial shifts, both natural andprobiotic-induced, affect maternal and fetal health and highlights potential opportunities for theinnovative use of probiotics during the gestation period.
One pager
Read the full paper
This work was commissionned by the Probiotics Task Force
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Download the full article here
or click on the image below to download the one-pager summary.
Commissioned by the Prebiotics and Probiotics Task Forces.
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