Food Contaminants

Improving scientific knowledge on food contaminants to ensure safer products

Task Force Information

Objectives and list of Task Force
members

Contact Information

Contact details in case you have specific questions

Activity Overview

Overview of ongoing and upcoming activities

Expert Groups

Objectives, output and list of experts involved in each activity

Publications

List of publications of this
Task Force

Multimedia

Links to Task Force related documents, recordings and much more...

Completed Expert Groups

Details including experts involved of each activity

Task Force Information

Objectives

As food contaminants poses a threat to consumers’ health, it is crucial to improve our knowledge about them. As such, the Food Contaminants Task Force.

  • Advance scientific knowledge on food contaminants – process-related contaminants, natural toxins, and other environmental contaminants – particularly focusing on assessing impacts on human health
  • Address research gaps in toxicity, exposure, and analytical aspects of food contaminants
  • Review & evaluate mitigation measures and support for risk management strategies for food contaminants.

Task Force Members

* Scientific Advisors

Contact Information

For more detailed information, please contact Konrad Korzeniowski at kkorzeniowski@ilsieurope.be or Belinda Antonio at bantonio@ilsieurope.be

Activity Overview

Update on Risk-Benefit Assessment of foods: approaches to facilitate application - Ongoing -

Objectives

An expert group on risk-benefits assessment of foods explores the reasons for limited application and seek practical solutions to increase the utility of this methodology in foods.

Prioritisation of natural toxins for risk management action based on both public health risk and mitigation efficacy - Upcoming -

Objectives

An expert group on prioritisation of natural toxins for risk management action will kick-off end of 2022. This activity will establish a framework for the prioritisation of natural toxins in foods following a risk-based approach.

New activity on the definition of Food Contaminants - Upcoming -

Objectives

This activity aims to gather and combine definitions of food contaminants and organise a workshop with a publication as an output.

- Upcoming -

Early career scientists’ event will take place in the Q1 of 2023

Expert Groups

Update on Risk-Benefit Assessment of foods: approaches to facilitate application

Background and Objectives

All foods contain chemical and biological impurities some of which may be viewed as contaminants of toxicological or microbiological relevance, depending on the definition used. Classical risk assessment does not reconcile the benefit to health of the food against the potential effects of the contaminants or the impact of mitigation measures that may be applied to reduce contaminants. A contaminant-centric view of a food can result in an incomplete understanding of the net health benefits of food by groups such as policy makers.
As such, methods for the comparison between benefits and risks have been developed, including the publication of guidance materials. Despite the availability of guidance, there have been a limited number of examples of risk-benefit analysis being used as an input for the risk management of foods by food safety agencies.

Output

This activity will review the evolution and application of risk-benefit assessment since its infancy, and thereby understand:
  • Why risk-benefit assessment has not been more widely applied by food safety agencies in Europe?
  • What are the available applications of RBA since the publication of guidance and what are the lessons learned?
  • Whether existing guidance can be amended to improve applicability?
  • The above learnings will be tested via a limited number of worked examples and summarized in a peer-reviewed publication.

Expert Group Members

Publications

All Publications

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => Process Related Compounds and Natural Toxins
            [authors] => 
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Process Related Compounds and Natural Toxins
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => Process Related Compounds and Natural Toxins
            [authors] => 
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Process Related Compounds and Natural Toxins
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
             => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
            [taxonomy] => ilsi_committee
            [term_id] => Process Related Compounds and Natural Toxins
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [terms] => Array
                                (
                                    [0] => Process Related Compounds and Natural Toxins
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_3_term_relationships
                )

            [queried_terms] => Array
                (
                    [ilsi_committee] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => Process Related Compounds and Natural Toxins
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_3_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_3_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_3_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_3_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_3_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_3_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_3_posts.ID
					FROM wp_3_posts  LEFT JOIN wp_3_term_relationships ON (wp_3_posts.ID = wp_3_term_relationships.object_id) INNER JOIN wp_3_postmeta ON ( wp_3_posts.ID = wp_3_postmeta.post_id )
					WHERE 1=1  AND ( 
  wp_3_term_relationships.term_taxonomy_id IN (23)
) AND ( 
  wp_3_postmeta.meta_key = '_ilsi_date'
) AND ((wp_3_posts.post_type = 'publication' AND (wp_3_posts.post_status = 'publish' OR wp_3_posts.post_status = 'acf-disabled')))
					GROUP BY wp_3_posts.ID
					ORDER BY wp_3_postmeta.meta_value DESC
					LIMIT 0, 5
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 10609
                    [post_author] => 24
                    [post_date] => 2022-03-29 08:35:38
                    [post_date_gmt] => 2022-03-29 08:35:38
                    [post_content] => 

Food Contaminants Task Force

FOOD RELATED CONTAMINANTS

The "totality" of the human exposure is conceived to encompass life-associated endogenous and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only formed in foods by heat processing, but also occur endogenously in the organism as physiological components of energy metabolism, potentially also generated by the human microbiome. To arrive at a comprehensive risk assessment, it is necessary to understand the contribution of in vivo background occurrence as compared to the ingestion from exogenous sources. Hence, this review provides an overview of the knowledge on the contribution of endogenous exposure to the overall exposure to putative genotoxic food contaminants, namely ethanol, acetaldehyde, formaldehyde, acrylamide, acrolein, α,β-unsaturated alkenals, glycation compounds, N-nitroso compounds, ethylene oxide, furans, 2- and 3-MCPD, and glycidyl esters. The evidence discussed herein allows to conclude that endogenous formation of some contaminants appears to contribute substantially to the exposome. This is of critical importance for risk assessment in the cases where endogenous exposure is suspected to outweigh the exogenous one (e.g. formaldehyde and acrolein).

Link to download the full-text

Keywords Expand

Endogenous exposure; Exposome; Genotoxins; Process-related contaminants

[post_title] => The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => the-role-of-endogenous-versus-exogenous-sources-in-the-exposome-of-putative-genotoxins-and-consequences-for-risk-assessment [to_ping] => [pinged] => [post_modified] => 2022-06-15 07:51:00 [post_modified_gmt] => 2022-06-15 07:51:00 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.eu/?post_type=publication&p=10609 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [1] => WP_Post Object ( [ID] => 9231 [post_author] => 343 [post_date] => 2021-05-31 08:22:17 [post_date_gmt] => 2021-05-31 08:22:17 [post_content] =>

Process-Related Compounds and Natural Toxins Task Force

FOOD RELATED CONTAMINANTS

Mineral Oil Hydrocarbons may unintentionally contaminate food through different routes across food chains and the lifecycle of food contact materials.

Gaps in the knowledge about mineral oil hydrocarbons (MON) still exist despite the recent advances in the research field.

A workshop to identify those gaps was organized by the European Branch of the International Life Science Institute.

Some of these were identified to be:

  • the lack of validated and standardized analytical methods for relevant food matrices, and
  • gaps in assessing the risk for consumers' health.

The consensus is that the lack of standardized, validated analytical methods able to assure good inter-laboratory reproducibility is the main gap underlining most of the existing difficulties to understand MOH.

In order to conduct adequate substance identification and quantification for input into risk assessment, the need for confirmatory methods that provide a detailed characterization of the unresolved complex mixtures needs to be solved.

The limited number of surveys covering a wide range of foods and enough samples to detect major sources of contamination other than packaging in paperboard also hinders reliable exposure estimation.

Fig. 4. Decision tree to identify auxilary methods. Adapted from Bratinova & Hoekstra, 2019. ALOX: Al2O3.
Decision tree to identify auxilary methods. (Adapted from Bratinova & Hoekstra, 2019)

Industry sectors represented in the workshop

  • Food & Drink
  • Mineral Oil/Waxes
  • Testing Laboratories
  • Analytical Instruments
  • Food Contact Materials
  • Cosmetics
  • Petroleum

Read the full-text article here

Scientific abstract Expand Background
In recent years there have been significant advancements in the understanding of mineral oil hydrocarbons (MOH) in foods and their potential risk to health. However, important gaps in knowledge remain, such as the lack of validated and standardized analytical methods for relevant food matrices and gaps in assessing the risk for consumers' health. Scope & approach
A workshop was organized by the European Branch of the International Life Science Institute to identify knowledge gaps in analytical methods, assessment of exposure, hazard characterisation, and risk assessment of MOH. This work captures the outcome of the workshop and builds upon it by combining the perspectives of the participants with an updated review of the literature to provide a roadmap for future management of the topic. Key findings and conclusions
Most participants to the workshop agreed that the key issue underlying many of the knowledge gaps in the field of MOH risk analysis and management is the lack of standardized, validated analytical methods able to assure good inter-laboratory reproducibility and to enable understanding of MOH occurrence in foods. It has been demonstrated that method EN 16995 used for MOH determination in vegetable oils and fats is not reliable below 10 mg/kg of food. There is also a need for confirmatory methods that provide a detailed characterization of the unresolved complex mixture observed from one-dimensional chromatographic methods. This is required to enable adequate substance identification and quantification for input into risk assessment. A major gap in the exposure estimation is the limited number of surveys covering a wide range of foods and enough samples to detect major sources of contamination other than packaging in paperboard. Data on concentration of MOH fractions in human body needed to determine internal exposure estimates is scarce. Data relating concentration in tissues with personal data, lifestyle, food intake and the use of cosmetics are needed to clarify the complex system of distribution of MOSH in the body and to possibly establish relationship between external and internal exposure. Additional toxicological studies to better characterize the hazards of relevant MOH are required for a better human health risk assessment. Keywords Expand

Mineral oil hydrocarbon, Risk assessment, Exposure assessment, Food contaminant, MOSH, MOAH

Number of participants in the workshop 61 from Academica, Public organisations, and Industry. EN 16995 used for MOH determination in vegetable oils and fats is not reliable below 10 mg/kg of food. Main indetified gaps in the knowledge of Mineral Oil Hydrocarbons 8

To enable human risk assessment, the performance of toxicological studies on the relevant MOH mixtures and possibly their components is required.

This work was conducted in collaboration with the Packaging Materials Task Force.

[post_title] => Mineral oil risk assessment: Knowledge gaps and roadmap. Outcome of a multi-stakeholders workshop [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => mineral-oil-risk-assessment-knowledge-gaps-and-roadmap-outcome-of-a-multi-stakeholders-workshop [to_ping] => [pinged] => [post_modified] => 2022-03-31 06:46:09 [post_modified_gmt] => 2022-03-31 06:46:09 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.eu/?post_type=publication&p=9231 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [2] => WP_Post Object ( [ID] => 6672 [post_author] => 24 [post_date] => 2019-09-05 10:10:48 [post_date_gmt] => 2019-09-05 10:10:48 [post_content] => [post_title] => Practical Guidance to Mitigation of Mycotoxins During Food Processing [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => practical-guidance-to-mitigation-of-mycotoxins-during-food-processing [to_ping] => [pinged] => [post_modified] => 2022-04-06 10:24:15 [post_modified_gmt] => 2022-04-06 10:24:15 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.eu/?post_type=publication&p=6672 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [3] => WP_Post Object ( [ID] => 5280 [post_author] => 24 [post_date] => 2018-02-22 08:19:34 [post_date_gmt] => 2018-02-22 08:19:34 [post_content] => [post_title] => Exposure Assessment of Process-Related Contaminants in Food by Biomarker Monitoring [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => exposure-assessment-of-process-related-contaminants-in-food-by-biomarker-monitoring [to_ping] => [pinged] => [post_modified] => 2018-09-18 10:22:37 [post_modified_gmt] => 2018-09-18 10:22:37 [post_content_filtered] => [post_parent] => 0 [guid] => http://ilsi.eu/?post_type=publication&p=5280 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [4] => WP_Post Object ( [ID] => 2907 [post_author] => 24 [post_date] => 2016-09-01 11:45:15 [post_date_gmt] => 2016-09-01 11:45:15 [post_content] => [post_title] => Impact of Food Processing and Detoxification Treatments on Mycotoxin Contamination [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => impact-of-food-processing-and-detoxification-treatments-on-mycotoxin-contamination [to_ping] => [pinged] => [post_modified] => 2017-09-26 12:47:14 [post_modified_gmt] => 2017-09-26 12:47:14 [post_content_filtered] => [post_parent] => 0 [guid] => http://ilsi.eu/?post_type=publication&p=2907 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) ) [post_count] => 5 [current_post] => -1 [in_the_loop] => [post] => WP_Post Object ( [ID] => 10609 [post_author] => 24 [post_date] => 2022-03-29 08:35:38 [post_date_gmt] => 2022-03-29 08:35:38 [post_content] =>

Food Contaminants Task Force

FOOD RELATED CONTAMINANTS

The "totality" of the human exposure is conceived to encompass life-associated endogenous and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only formed in foods by heat processing, but also occur endogenously in the organism as physiological components of energy metabolism, potentially also generated by the human microbiome. To arrive at a comprehensive risk assessment, it is necessary to understand the contribution of in vivo background occurrence as compared to the ingestion from exogenous sources. Hence, this review provides an overview of the knowledge on the contribution of endogenous exposure to the overall exposure to putative genotoxic food contaminants, namely ethanol, acetaldehyde, formaldehyde, acrylamide, acrolein, α,β-unsaturated alkenals, glycation compounds, N-nitroso compounds, ethylene oxide, furans, 2- and 3-MCPD, and glycidyl esters. The evidence discussed herein allows to conclude that endogenous formation of some contaminants appears to contribute substantially to the exposome. This is of critical importance for risk assessment in the cases where endogenous exposure is suspected to outweigh the exogenous one (e.g. formaldehyde and acrolein).

Link to download the full-text

Keywords Expand

Endogenous exposure; Exposome; Genotoxins; Process-related contaminants

[post_title] => The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => the-role-of-endogenous-versus-exogenous-sources-in-the-exposome-of-putative-genotoxins-and-consequences-for-risk-assessment [to_ping] => [pinged] => [post_modified] => 2022-06-15 07:51:00 [post_modified_gmt] => 2022-06-15 07:51:00 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.eu/?post_type=publication&p=10609 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [comment_count] => 0 [current_comment] => -1 [found_posts] => 13 [max_num_pages] => 3 [max_num_comment_pages] => 0 [is_single] => [is_preview] => [is_page] => [is_archive] => 1 [is_date] => [is_year] => [is_month] => [is_day] => [is_time] => [is_author] => [is_category] => [is_tag] => [is_tax] => 1 [is_search] => [is_feed] => [is_comment_feed] => [is_trackback] => [is_home] => [is_privacy_policy] => [is_404] => [is_embed] => [is_paged] => [is_admin] => [is_attachment] => [is_singular] => [is_robots] => [is_favicon] => [is_posts_page] => [is_post_type_archive] => [query_vars_hash:WP_Query:private] => dd9e662ba9ceb45470e5341dfd67c856 [query_vars_changed:WP_Query:private] => [thumbnails_cached] => [stopwords:WP_Query:private] => [compat_fields:WP_Query:private] => Array ( [0] => query_vars_hash [1] => query_vars_changed ) [compat_methods:WP_Query:private] => Array ( [0] => init_query_flags [1] => parse_tax_query ) )

Multimedia

‘Mycotoxin Prevention and Control: Food Processing Mitigation Strategies’
Watch the Webinar

Podcast
Click here to watch the Podcast on 'Dietary Exposure Mitigation to Chemical Contaminants'

Completed Expert Groups

Overview of completed activities since 2021

* To see the full output of the task force, please visit the Task Force publication list