ILSI Europe disseminates science by publishing articles on original research, literature reviews and gap analyses, and meeting proceedings in peer-reviewed journals with high impact factors. ILSI Europe also publishes books, monographs, white papers, and other reports.
Discover below our latest scientific publications.
All Publications
A systematic review of iodine intake in children, adults, and pregnant women in Europe – comparison against dietary recommendations and evaluation of dietary iodine sources
Nutrition Reviews, 2022
Commissioned by the Nutrient Intake Optimisation Task Force
Practical Guidance on the Application of Food Allergen Quantitative Risk Assessment (QRA)
ILSI Europe Report Series, 2022
Commissioned by the Food Allergy Task Force.
The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review
Nutrients, 2022
Commissioned by the Obesity and Diabetes Task Force
Dietary Probiotics, Prebiotics and the Gut Microbiota in Human Health
2022
Commissioned by the Prebiotics and Probiotics Task Forces.
Animal-free strategies in food safety & nutrition: What are we waiting for? Part II: Nutrition research
Trends in Food Science & Technology, 2022
Commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force.
- Cross-contact / Contamination estimate calculator: A practical calculator to estimate the UAP in a product. This tool was initially developed by the EU project iFAAM and is kindly provided by TNO. It can be used for free after initial registration. Access here.
- QRA calculation worksheet v4.4: Download here.
- Incidents form: See Chapter 4 of the Guidance for more information. Download here.
- Sampling & Analysis form: Download here.
Training videos
- Webinar of 23 June 2022: Watch here.
- Management of Operations: to be published soon
- Incidents: to be published soon
Other resources
- Presentation slides from the training "Demystifying the Risks of Allergy Risk Assessment" held at Food Allergy Forum 2023 - Download here.
For more information about the Food Allergy Task Force click here.
[post_title] => Practical Guidance on the Application of Food Allergen Quantitative Risk Assessment (QRA) [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => practical-guidance-on-the-application-of-food-allergen-quantitative-risk-assessment-qra [to_ping] => [pinged] => [post_modified] => 2025-01-14 13:18:25 [post_modified_gmt] => 2025-01-14 13:18:25 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.eu/?post_type=publication&p=11040 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [2] => WP_Post Object ( [ID] => 10886 [post_author] => 24 [post_date] => 2022-05-30 07:04:45 [post_date_gmt] => 2022-05-30 07:04:45 [post_content] =>Obesity and Diabetes
Nutrition Security and Societal Aspects
Background: The gold-standard techniques for measuring insulin sensitivity and secretion are well established. However, they may be perceived as invasive and expensive for use in dietary intervention studies. Thus, surrogate markers have been proposed as alternative markers for insulin sensitivity and secretion. This systematic review aimed to identify markers of insulin sensitivity and secretion in response to dietary intervention and assess their suitability as surrogates for the gold-standard methodology. Methods: Three databases, PubMed, Scopus, and Cochrane were searched, intervention studies and randomised controlled trials reporting data on dietary intake, a gold standard of analysis of insulin sensitivity (either euglycaemic-hyperinsulinaemic clamp or intravenous glucose tolerance test and secretion (acute insulin response to glucose), as well as surrogate markers for insulin sensitivity (either fasting insulin, area under the curve oral glucose tolerance tests and HOMA-IR) and insulin secretion (disposition index), were selected. Results: We identified thirty-five studies that were eligible for inclusion. We found insufficient evidence to predict insulin sensitivity and secretion with surrogate markers when compared to gold standards in nutritional intervention studies. Conclusions: Future research is needed to investigate if surrogate measures of insulin sensitivity and secretion can be repeatable and reproducible in the same way as gold standards.
Keywords ExpandInsulin Sensitivity; Insulin Secretion; Gold Standard; Surrogate Markers; Dietary Intervention Studies
To download this open-access article, please click here.
This work was commissioned by the Obesity and Diabetes Task Force.
[post_title] => The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => the-use-and-effectiveness-of-selected-alternative-markers-for-insulin-sensitivity-and-secretion-compared-with-gold-standard-markers-in-dietary-intervention-studies-in-individuals-without-diabetes-res [to_ping] => [pinged] => [post_modified] => 2022-05-31 09:10:37 [post_modified_gmt] => 2022-05-31 09:10:37 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.eu/?post_type=publication&p=10886 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [3] => WP_Post Object ( [ID] => 10626 [post_author] => 24 [post_date] => 2022-04-06 14:11:57 [post_date_gmt] => 2022-04-06 14:11:57 [post_content] =>Citation: https://doi.org/10.5281/zenodo.6394212
The scientific understanding of prebiotic and probiotic mechanisms has grown substantially in recent years. Although effects are often strain and product specific, some prebiotic and probiotic benefits may be driven by common, shared mechanisms and may therefore be generalizable. The use of emerging physiological and analytical tools in a multidisciplinary research setting will enable the elucidation of further mechanisms. In this way, it will be possible to improve the understanding of prebiotic, probiotic and synbiotic health effects. Based on recent sound scientific evidence, the monograph is a valuable reference work, aimed at informing a wide audience about the intestinal microbiota and the prebiotic and probiotic nutritional concepts.
- To download the English version, click here.
- To download the Portuguese version, click here.
- To download the French version, click here.
- To download the Spanish version, click here.
- To download the Slovak version, click here.
- To download the Japanese version, click here.
- To download the Chinese version, click here.
Click on the image below to download the one-pager summary.
Commissioned by the Prebiotics and Probiotics Task Forces.
[post_title] => Dietary Probiotics, Prebiotics and the Gut Microbiota in Human Health [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => dietary-probiotics-prebiotics-and-the-gut-microbiota-in-human-health [to_ping] => [pinged] => [post_modified] => 2023-02-06 13:36:16 [post_modified_gmt] => 2023-02-06 13:36:16 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.eu/?post_type=publication&p=10626 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [4] => WP_Post Object ( [ID] => 10921 [post_author] => 24 [post_date] => 2022-05-31 08:54:54 [post_date_gmt] => 2022-05-31 08:54:54 [post_content] =>Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies
NEW APPROACHES FOR FOOD SAFETY
Background: Methods and approaches that can be used in food and nutrition research are changing at a faster pace than ever. Whereas animal methods are mostly known for their use in food safety analysis (see Part I), they also play in important role in proof-of-concept and mechanistic studies of products, as well as studying potency, efficacy, and tolerance of foods and food ingredients. Members of the International Life Sciences Institute (ILSI) Europe have formed an expert group to review possibilities, opportunities, and challenges for the potential use of alternative testing strategies in nutrition research and regulatory requirements, supporting the 3Rs principle of Replacement, Reduction, Refinement of animal research, which can ultimately be used in support of regulatory submissions for pre-market authorisation.Scope and approach: For the different areas of food for specific groups and health claims, the acceptability of non-animal approaches is evaluated in comparison to legislative requirements in Europe. The alternative approaches considered cover emerging tools and methodologies such as organoids, organs-on-a-chip or human in vitro gastrointestinal simulators.
Conclusions: In nutrition research, there has been a long tradition of following a certain experimental trajectory for grounding scientific hypotheses starting from in vitro data moving on to in vivo verification in a preferred animal model and finally proving this in a human setting. From a regulatory perspective there is no specific requirement for animal experimentation that justifies the use of the majority of animal experiments in the
assessment of nutritional content and value of food products. However, animal data are mostly considered as the standard, and guidance for alternative approaches that would be accepted is lacking. It is therefore important to further build evidence and offer validation for the adequacy of already existing in vitro tools to ensure their suitability for substantiating dose levels and further planning clinical trials. What are we waiting for? Keywords Expand
Non-animal testing, Nutrition research, Regulation
To download this open-access article, please click here.
This work was commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force.
[post_title] => Animal-free strategies in food safety & nutrition: What are we waiting for? Part II: Nutrition research [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => animal-free-strategies-in-food-safety-nutrition-what-are-we-waiting-for-part-ii-nutrition-research [to_ping] => [pinged] => [post_modified] => 2023-04-13 14:52:34 [post_modified_gmt] => 2023-04-13 14:52:34 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.eu/?post_type=publication&p=10921 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) ) [post_count] => 5 [current_post] => -1 [before_loop] => [in_the_loop] => [post] => WP_Post Object ( [ID] => 11103 [post_author] => 24 [post_date] => 2022-06-29 09:16:43 [post_date_gmt] => 2022-06-29 09:16:43 [post_content] =>Nutrient Intake Optimisation
Adequate iodine intake is essential throughout life. Key dietary sources are iodized salt and animal products, but dietary patterns in Europe are changing, for example toward lower salt intake and a more plant-based diet.
The objective of this systematic review was to review iodine intake (not status) in European populations (adults, children, and pregnant women) to identify at-risk groups and dietary sources. In total, 57 studies were included, comprising 22 national surveys and 35 sub-national studies. Iodine intake data were available from national surveys of children aged <10 years (n = 11), 11-17 years (n = 12), and adults (n = 15), but data from pregnancy were only available from sub-national studies.
We show that iodine intake data are lacking-only 17 of 45 (38%) European countries had iodine-intake data from national surveys. Iodine intake reported from national surveys was below recommendations for: (1) children aged <10 years in 2 surveys (18%), (2) boys and girls aged 11-17 years in 6 (50%) and 8 (68%) surveys, respectively, and (3) adult men and women in 7 (47%) and 12 (80%) surveys, respectively. In pregnant women, intake was below recommendations except where women were taking iodine-containing supplements. Just 32% of national surveys (n = 7) included iodized salt when estimating iodine intake. Milk, dairy products, fish, and eggs were important contributors to intake in many countries, suggesting limited sources in plant-based diets.
Results are limited by the challenges of dietary assessment for measuring iodine intake. Future national surveys should include iodine intake. Policy makers should consider dietary sources alongside any iodized salt policies when considering methods for improving population iodine intake.
Keywords ExpandAdults, children, diet, Europe, fish, iodized, iodine, intake, milk, pregnancy
To download this open-access article, please click here.
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