ILSI Europe disseminates science by publishing articles on original research, literature reviews and gap analyses, and meeting proceedings in peer-reviewed journals. ILSI Europe also publishes books, monographs, white papers, and other reports.
Commissioned by the Prebiotics and Probiotics Task Forces
Commissioned by the Nutrient Intake Optimisation Task Force
Commissioned by the Food Allergy Task Force.
Commissioned by the Obesity and Diabetes Task Force
ILSI Europe Concise Monograph. Commissioned by the Prebiotics and Probiotics Task Forces.
- Cross-contact / Contamination estimate calculator: A practical calculator to estimate the UAP in a product can be found here. This tool was initially developed by the EU project iFAAM and is kindly provided by TNO. It can be used for free after initial registration.
- QRA calculation worksheet v4.4: download here.
- Incidents form: For download here. See Chapter 4 of the Guidance for more information.
- Sampling & Analysis form: download here.
Training videos for this Guidance
- Management of Operations: to be published soon
- Incidents: to be published soon
For more information about the Food Allergy Task Force click here.[post_title] => Practical Guidance on the Application of Food Allergen Quantitative Risk Assessment (QRA) [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => practical-guidance-on-the-application-of-food-allergen-quantitative-risk-assessment-qra [to_ping] => [pinged] => [post_modified] => 2022-06-28 08:42:48 [post_modified_gmt] => 2022-06-28 08:42:48 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.eu/?post_type=publication&p=11040 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw )  => WP_Post Object ( [ID] => 10886 [post_author] => 24 [post_date] => 2022-05-30 07:04:45 [post_date_gmt] => 2022-05-30 07:04:45 [post_content] =>
Obesity and Diabetes
Nutrition Security and Societal Aspects
Background: The gold-standard techniques for measuring insulin sensitivity and secretion are well established. However, they may be perceived as invasive and expensive for use in dietary intervention studies. Thus, surrogate markers have been proposed as alternative markers for insulin sensitivity and secretion. This systematic review aimed to identify markers of insulin sensitivity and secretion in response to dietary intervention and assess their suitability as surrogates for the gold-standard methodology. Methods: Three databases, PubMed, Scopus, and Cochrane were searched, intervention studies and randomised controlled trials reporting data on dietary intake, a gold standard of analysis of insulin sensitivity (either euglycaemic-hyperinsulinaemic clamp or intravenous glucose tolerance test and secretion (acute insulin response to glucose), as well as surrogate markers for insulin sensitivity (either fasting insulin, area under the curve oral glucose tolerance tests and HOMA-IR) and insulin secretion (disposition index), were selected. Results: We identified thirty-five studies that were eligible for inclusion. We found insufficient evidence to predict insulin sensitivity and secretion with surrogate markers when compared to gold standards in nutritional intervention studies. Conclusions: Future research is needed to investigate if surrogate measures of insulin sensitivity and secretion can be repeatable and reproducible in the same way as gold standards.Keywords Expand
Insulin Sensitivity; Insulin Secretion; Gold Standard; Surrogate Markers; Dietary Intervention Studies
To download this open-access article, please click here.
This work was commissioned by the Obesity and Diabetes Task Force.[post_title] => The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => the-use-and-effectiveness-of-selected-alternative-markers-for-insulin-sensitivity-and-secretion-compared-with-gold-standard-markers-in-dietary-intervention-studies-in-individuals-without-diabetes-res [to_ping] => [pinged] => [post_modified] => 2022-05-31 09:10:37 [post_modified_gmt] => 2022-05-31 09:10:37 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.eu/?post_type=publication&p=10886 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw )  => WP_Post Object ( [ID] => 10626 [post_author] => 24 [post_date] => 2022-04-06 14:11:57 [post_date_gmt] => 2022-04-06 14:11:57 [post_content] =>
GUT MICROBIOME AND HEALTH
The scientific understanding of prebiotic and probiotic mechanisms has grown substantially in recent years. Although effects are often strain and product specific, some prebiotic and probiotic benefits may be driven by common, shared mechanisms and may therefore be generalizable. The use of emerging physiological and analytical tools in a multidisciplinary research setting will enable the elucidation of further mechanisms. In this way, it will be possible to improve the understanding of prebiotic, probiotic and synbiotic health effects. Based on recent sound scientific evidence, the monograph is a valuable reference work, aimed at informing a wide audience about the intestinal microbiota and the prebiotic and probiotic nutritional concepts.
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GUT MICROBIOME AND HEALTH
Together with proteins and fats, carbohydrates are one of the macronutrients in the human diet. Digestible carbohydrates, such as starch, starch-based products, sucrose, lactose, glucose and some sugar alcohols and unusual (and fairly rare) α-linked glucans, directly provide us with energy while other carbohydrates including high molecular weight polysaccharides, mainly from plant cell walls, provide us with dietary fibre. Carbohydrates which are efficiently digested in the small intestine are not available in appreciable quantities to act as substrates for gut bacteria. Some oligo- and polysaccharides, many of which are also dietary fibres, are resistant to digestion in the small intestines and enter the colon where they provide substrates for the complex bacterial ecosystem that resides there. This review will focus on these non-digestible carbohydrates (NDC) and examine their impact on the gut microbiota and their physiological impact. Of particular focus will be the potential of non-digestible carbohydrates to act as prebiotics, but the review will also evaluate direct effects of NDC on human cells and systemsKeywords Expand
Prebiotics, short-chain fatty acids (SCFA), non-digestible carbohydrates
To download this open-access article, please click here.
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