A to Z
Analytical Methods for the Screening of Potential Volatile Migrants from Acrylic-Base Adhesives Used in Food-Contact Materials
2009
- ILSI Europe
Food Additives and Contaminants: Part A. 2009;26(12):1592-1601.
Animal-Free Strategies in Food Safety & Nutrition: What Are we Waiting For? Part I: Food Safety
2020
- ILSI Europe
Trends in Food Science & Technology 2020. Commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force.
Animal-free strategies in food safety & nutrition: What are we waiting for? Part II: Nutrition research
Trends in Food Science & Technology, 2022
- ILSI Europe
Commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force.
Appetite Control: Methodological Aspects of the Evaluation of Foods
2010
- ILSI Europe
Obesity Reviews. 2010;11(3):251-270
Application of Scientific Criteria to Food Allergens of Public Health Importance
2012
- ILSI Europe
Regulatory Toxicology and Pharmacology. 2012;64(2):315-323. Commissioned by the Food Allergy Task Force.
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Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies
NEW APPROACHES FOR FOOD SAFETY
Background: Methods and approaches that can be used in food and nutrition research are changing at a faster pace than ever. Whereas animal methods are mostly known for their use in food safety analysis (see Part I), they also play in important role in proof-of-concept and mechanistic studies of products, as well as studying potency, efficacy, and tolerance of foods and food ingredients. Members of the International Life Sciences Institute (ILSI) Europe have formed an expert group to review possibilities, opportunities, and challenges for the potential use of alternative testing strategies in nutrition research and regulatory requirements, supporting the 3Rs principle of Replacement, Reduction, Refinement of animal research, which can ultimately be used in support of regulatory submissions for pre-market authorisation.
Scope and approach: For the different areas of food for specific groups and health claims, the acceptability of non-animal approaches is evaluated in comparison to legislative requirements in Europe. The alternative approaches considered cover emerging tools and methodologies such as organoids, organs-on-a-chip or human in vitro gastrointestinal simulators.
Conclusions: In nutrition research, there has been a long tradition of following a certain experimental trajectory for grounding scientific hypotheses starting from in vitro data moving on to in vivo verification in a preferred animal model and finally proving this in a human setting. From a regulatory perspective there is no specific requirement for animal experimentation that justifies the use of the majority of animal experiments in the
assessment of nutritional content and value of food products. However, animal data are mostly considered as the standard, and guidance for alternative approaches that would be accepted is lacking. It is therefore important to further build evidence and offer validation for the adequacy of already existing in vitro tools to ensure their suitability for substantiating dose levels and further planning clinical trials. What are we waiting for?
Keywords
Expand
Non-animal testing, Nutrition research, Regulation
To download this open-access article, please click here.
This work was commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force.
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