Course at EuroTox 2015 on “Thresholds of Toxicological Concern – Basics and Latest Developments”

EuroTox 2015
Porto, Portugal


ILSI Europe organised a Continuing Education Course (CEC) during EuroTox 2015.


You can download the course flyer here.


Continuing Education Course on 'Thresholds of Toxicological Concern – Basics and Latest Developments'
13 September 2015, 9.30-16.00
Chairs:  Dr Kirstin Kosemund & Dr Sue Barlow

Introduction to the CEC on TTC
Dr Sue Barlow, Consultant Toxicologist, UK

Introduction into the Tiered TTC Concept and Regulatory Status Globally 
Dr Kirstin Kosemund, Procter & Gamble, DE

Cancer Thresholds, Cohort of Concern and Excluded Substance Groups 
Prof. Alan Boobis, Imperial College London, UK

Non-cancer Oral Toxicity Databases for TTC 
Dr Sue Barlow, Consultant Toxicologist, UK

Estimation of Toxic Hazard – A Revised Cramer-Ford-Hall Decision Tree  
Dr Jürgen Schnabel, Givaudan, CH

Computational Modelling for TTC Assessment  
Dr Andrew Worth, European Commission - Joint Research Centre, IT

TTC Concept: Non-oral Routes and Influence of Local Effects 
Dr Sylvia Escher,  Fraunhofer Institut fur Toxikologie & Experimentelle Medizin, DE


With the rising acknowledgement by EU authoritative bodies of the value of the Threshold of Toxicological Concern Concept (TTC), it becomes increasingly important for toxicologists involved in safety assessments to understand the scientific basis of the concept and its current status. As with other alternative methods feeding into intelligent testing strategies, such as in vitro testing, (Q)SAR and read-across, the TTC is a tool for experts, and requires understanding of its power, value, and boundaries.

This CEC was designed to provide an overview of the basic scientific principles of the tiered TTC approach and its potential applications for safety assessments for different product types in different regions, but also to present most up to date knowledge and progress on specific endpoints and methods.

The talks gave an overview of the toxicity datasets on which the TTC thresholds for cancer and non-cancer effects are based, if and how non-oral routes of exposure and local effects are represented in the databases, and can be addressed by the thresholds. The Cramer Class grouping scheme for non-cancer toxicity potency was introduced, as well as updates to the Cramer Classes or other potency grouping approaches. Criteria and tools to examine applicability of the TTC concept to different types of chemistries and natural substances were discussed to enable participants to develop an understanding of the confidence in the assessment of a given substance by TTC thresholds.


For more information about this course, please contact Dr Jackie Whyte, Scientific Project Manager at


Visit the EuroTox 2015's website.