Digital Event, Microsoft Teams
19/04/2021 – 21/04/2021
1:30 pm – 5:30 pm
About the workshop
Building on the evaluation of the Cancer Potency Database (CPDB) developed by the ILSI Europe CPDB Expert Group the joint research project ‘Carcinogen Dose-Response Database for TTC’ (B18) supported by ILSI Europe, Liverpool John Moores University (UK), Molecular Networks GmbH (DE), Fraunhofer Institute for Toxicology and Experimental Medicine (DE) and the European Chemical Industry Council Long-Range Research Initiative (CEFIC LRI) aims to generate a fully-curated, quality-controlled and publically-available database on cancer potency data for genotoxic and non-genotoxic carcinogens. The add-on project B18.2, run by Fraunhofer ITEM, collected non-cancer endpoint data for the non-DNA-reactive subset of carcinogens of B18.
A broad range of stakeholders including US FDA, EFSA, WHO, JRC etc. had voiced in previous evaluations of the TTC cancer thresholds that it would be advisable to update and reanalyse the cancer database forming the basis of the current TTC threshold. Consequently, the organisation of a workshop is envisaged in order to discuss the results of the joint project with relevant experts familiar with cancer data interpretation and TTC. In particular, the workshop aims:
- To introduce the final database and the methods applied
- To achieve consensus on
- appropriate study and data selection
- the preferred statistical approach to biologically relevant cancer potency descriptors
- should the expert group agree that an update of the existing TTC threshold of 0.15 µg/person/day were warranted, on appropriate extrapolation for practical TTC cancer thresholds
- To develop recommendations for optimal use of the cancer potency database
Participation on this workshop is possible upon invitation.