Advancements in toxicological hazard and risk Assessment for food safety: exploring new approach Methodologies and predictive models

Brussels, Belgium


This training aims at providing state-of-the-art knowledge on the recent developments in toxicological hazard and risk assessment, with an emphasis on the application in food safety. A limited number of lectures will provide insight in these developments, emphasizing the role of so-called new approach methodologies (NAMs). In 2016, an ILSI Expert Group published a paper where a flow sheet illustrated the role of different aspects of the process of risk or safety assessment and thereby avoiding the use of animal models. Integrating these aspects, ranging from interpreting knowledge on the chemistry of compounds (and mixtures), exposure, in vitro toxicity and kinetic behaviour, may result in the possibility to predict safety. Course participants will apply the presented flow sheet for a selection of food ingredients in case studies. During the 2-day in person training, a manuscript will be drafted to publish the results of the case studies; participants have the option to be co-author of this publication. Participants are welcome to test the flow sheet on their own data.


Prof B. Blaauboer, University of Utrecht, NL
Prof M. Vinken, Free University Brussels, BE

Target participants

Open to all industry experts involved in toxicological risk assessment of compounds, mainly but not exclusively of compounds in food or food ingredients.


• General overview of hazard and risk assessment procedures, past and future.
• Cytotoxicity, how to measure it and how to interpret it.
• Understanding mechanisms of action of toxicity: Adverse Outcome Pathways.
• Understanding the kinetic behaviour of chemicals in biological systems (in vitro as well as in vivo): short intro in Physiologically-based kinetic modelling (PBK).
• Quantitative In Vitro-In Vivo extrapolation (QIVIVE).

Registration and cost

• ILSI Europe member: 2.000€
• Non-member: 2.500€

Register here before 15th December.