New tools in the assessment of toxicity focus on developing a better mechanistic understanding of the biological interactions and pathways involved, through the application of cellular and molecular based methods, combined with computational approaches. This task force investigates how these new approaches may have applications in risk assessment that are relevant to the development of safe food and food ingredients.
This task force aims to be at the forefront of advances in toxicity testing, proposing guidance on the utility, development and application of novel methodologies to assess hazard and risk in the food chain.
- Innovation for the food industry in the future will be dependent on being able to conduct risk assessments on new food and food ingredients. The food industry needs to engage in the development of these new approaches to support future innovation.
- The task force recently published a roadmap that can be applied to evaluate the toxicological safety of foods and food ingredients (B.J. Blaauboer et al., 2016).
- The task force intends to organise a joint workshop at EuroTox2018 with the Alternatives for Animal Testing in Food Safety, Nutrition and Efficacy Testing Task Force and ILSI HESI.
For more detailed information, please contact Dr Bettina Schelkle at email@example.com
Exploitation of ToxCast Data on Food Chemicals for Safety Risk Assessment
A high throughput screening programme of chemicals for potential toxicity (ToxCast) was performed by the Environmental Protection Agency (EPA). The ToxCast Expert Group aims to exploit the data relevant to the food industry from the ToxCast programme and to assess the utility of the data and methods for their use in the safety risk assessment of food chemicals.
The intention is to build on earlier work commissioned by ILSI North America in which approximately 800 food relevant chemicals within the ToxCast programme were identified through conducting approximately 860 in vitro biological assays / endpoints.
This activity will draw conclusions from the chemical structure of food-relevant compounds to assess their safety for human consumption and handling. An Adverse Outcome Pathway (AOP) may be developed based on these conclusions.
Food and Chemical Toxicology. 2016;91:19-35. Commissioned by the New Approaches to Chemical Risk Assessment Task Force.
Regulatory Toxicology and Pharmacology. 2014;68(2):275-296. Commissioned by the Risk Assessment of Chemicals in Food Task Force.
ILSI Europe Report Series. 2012:1-24. Commissioned by the Risk Assessment of Chemicals in Food Task Force and the Process-related Compounds & Natural Toxins Task Force.
Food and Chemical Toxicology. 2003;41(9):1205-1271.