Exploring new toxicological safety assessment technologies for the food industry

Background

New tools in toxicity testing focus on the application of cellular and molecular based methods, combined with an understanding of biological pathways and networks, to assess how their functioning is affected by exposure to chemicals. This task force investigates how the food industry, which has so far been slow to implement these tools, can benefit from these developments.

Objectives

This task force aims to be at the forefront of advances in toxicity testing, proposing guidance on the utility, development and application of novel methodologies to assess hazard and risk in the food chain.

Impact

Future innovation in the food industry will be supported through assessing the utility of toxicological tools mentioned in the 2007 National Research Council (NRC) report, ‘Toxicity Testing in the 21st Century (TT21C): a Vision and a Strategy’, for their relevance and potential application in food processing.

What’s New

The task force recently published a roadmap that can be applied to evaluate the toxicological safety of foods and food ingredients (B.J. Blaauboer et al., 2016).

The task force is now working on exploiting ToxCast data to assess how they can be used to assess risks in the food industry.

For more detailed information, please contact Dr Bettina Schelkle at bschelkle@ilsieurope.be

Task Force Members

Dr Anette Thiel – Chair DSM CH
Dr Paul Hepburn – Vice-Chair Unilever UK
Prof. Alan Boobis – Co-Chair Imperial College London UK
Dr Sylvain Etter Firmenich CH
Dr Karma Fussell Nestlé CH
Dr Jossie Garthoff Danone NL
Dr Brett Jeffery Mars Chocolate UK
Dr Heinz Traussnig Mayr-Melnhof Karton AT
Dr Bettina Schelkle ILSI Europe BE

 

Expert Group

Exploitation of Toxcast Data on Food Chemicals for Safety Risk Assessment

Objectives

A high throughput screening programme of chemicals for potential toxicity (ToxCast) was performed by the Environmental Protection Agency (EPA). The ToxCast Expert Group aims to exploit the data relevant to the food industry from the ToxCast programme and to assess the utility of the data and methods for their use in the safety risk assessment of food chemicals.

Activity

The intention is to build on earlier work commissioned by ILSI North America in which approximately 800 food relevant chemicals within the ToxCast programme were identified through conducting approximately 860 in vitro biological assays / endpoints.

Expected Outcome

This activity will draw conclusions from the chemical structure of food-relevant compounds to assess their safety for human consumption and handling. An Adverse Outcome Pathway (AOP) may be developed based on these conclusions.

Expert Group Members

Dr Ans Punt – Chair University of Wageningen and Research Institute (RIKILT) NL
Dr Paul Hepburn – Vice-Chair Unilever UK
Prof. Alan Boobis Imperial College London UK
Prof. Mark Cronin Liverpool John Moores University UK
Dr Sylvain Etter Firmenich CH
Dr John Paul Gosling University of Leeds UK
Dr Jochem Louisse University of Wageningen NL
Dr Benoît Schilter Nestlé CH
Dr Anette Thiel DSM CH
Prof. Martin Wilks University of Basel CH
Dr Bettina Schelkle ILSI Europe BE

 

Publications

All Publications

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